Levofloxacin+Tetracycline Quadruple Regimen for Eradication of <i>Helicobacter pylori</i>: A Multicenter Multinational Randomized Controlled Trial
نویسندگان
چکیده
Background: The ideal combination regimen for Helicobacter pylori (HP) eradication has not yet been determined and the success rate of HP extensively reduced worldwide due to increasing antibiotic resistance. So this multinational multi-center randomized controlled trial was designed evaluate efficacy tetracycline +levofloxacin eradication. Methods: During a 6-month period, all cases with infection in eight referral tertiary centers three countries were included randomly allocated receive either + levofloxacin or clarithromycin plus amoxicillin quadruple two weeks. For participants, pantoprazole continued 4 more weeks after one off-therapy, they underwent urea breath test C13 prove Results: Overall 788 patients (358 male (45.4%), average age 44.2 years). They diagnosed as having non-ulcer dyspepsia (516 cases, 65.5%), peptic ulcer disease (PUD) (234 29.69%), intestinal metaplasia (38 4.8%). Racially 63.1% Caucasian, 14.5% Arab, 15.6% African, 6.1% Asian. participants groups A B clarithromycin. Among intention treat (ITT) per protocol (PP) analysis, 75.2% & 82.1% (285 cases) 67.5% 70.1% (276 achieved eradication, respectively (P = 0.0001). complete compliance 84.4% 83.6%, respectively. study, 33.5% group (127 reported side effects while complication among 27.9% (114 P 0.041). most common complaints nausea vomiting (12.6% 9.3%) abdominal pain (4.48% 2.68%), severe complications that caused discontinuation medication 2.1% 1.46%, 679). In subgroup rates tetracycline+levofloxacin dyspepsia, PUD, 79.4%, 88.1%, 73.9%, These figures (clarithromycin base) 71.3%, 67.6%, 61.5% 0.0001, 0.043). Conclusion: Overall, is efficient comparison clarithromycin+amoxicillin despite rate. areas high resistance clarithromycin, therapeutic could be an choice especially those who PUD.
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ژورنال
عنوان ژورنال: Middle East Journal of Digestive Diseases
سال: 2023
ISSN: ['2008-8205', '2008-5249', '2008-5230']
DOI: https://doi.org/10.34172/mejdd.2023.314